Looking for an innovative, non-surgical solution to improve skin texture and hydration? Polynucleotides (PN) treatments offer a cutting-edge way to rejuvenate your skin from within. These regenerative injectables stimulate collagen production, repair damaged tissues, and hydrate the skin for a fresher appearance. Ideal for targeting fine lines, wrinkles, and skin laxity, Polynucleotides provide natural, long-lasting results with minimal downtime.
What are Polynucleotides?
Polynucleotides are an injectable product that contain the DNA from the gametes of either trout or salmon. The DNA is known to help regenerate and improve the skins texture, elasticity, hydration and tone. When injected into the skin, Polynucleotides stimulate the body’s regenerative processes, helping to restore hydration and encourage collagen and elastin production. This results in smoother, firmer skin and an overall revitalised appearance.
How does the treatment work?
Polynucleotides work by repairing skin damage at a cellular level, improving elasticity, texture, and tone. They are particularly effective for treating signs of aging, such as sagging skin, fine lines, and wrinkles, or even in cases of skin discoloration and scars.
Unlike traditional fillers, Polynucleotides do not add volume. Instead, they work to restore the skin’s natural structure and function by encouraging the skin’s regenerative abilities. The treatment also provides deep hydration by improving the skin’s ability to retain moisture, leaving it plumper and more youthful.
What to expect after treatment:
Minor redness, swelling, bumps or tenderness at the injection points is normal post treatment and usually resolves within 1-3 days.
When to expect results:
The results from your Polynucleotide treatment will not be immediate, but most patients begin to notice improvements within 2 to 4 weeks after their first session. The skin gradually becomes smoother and more hydrated as collagen production increases.
For optimal results, a series of 2 to 3 treatments, spaced about 3 to 4 weeks apart, is typically recommended. This allows the skin to fully absorb and respond to the Polynucleotides, giving you visible, long-lasting results.
The effects of Polynucleotides can last up to 6 to 12 months, depending on factors like age, skin condition, and lifestyle.
Why choose Persona Medical Aesthetics Minor & Cosmetic Surgery Clinic:
At Persona Medical Aesthetics, we take a personal yet professional approach to every treatment. During your free consultation with our medical team, you’ll have the chance to ask any questions and clear up any uncertainties.
Additionally, we are regulated by the Care Quality Commission, which is a legal requirement to perform minor skin surgery. This ensures that you are in safe, experienced hands throughout the entire process.
Furthermore, all treatments, procedures, and products at Persona undergo thorough research and careful selection by Dr. Lisa and our medical team, as above all, your safety and well-being remain our top priority.
Who carries out this procedure?
Medical Director Dr Lisa Delamaine, Nurse prescriber Lucy Elliot and Dr Lola carry out Polynucleotide treatments.

Lucy Kench2025-05-02Trustindex verifies that the original source of the review is Google. I have been a customer of persona for many years now and all the treatments I have received have always left me smiling , all the staff are polite and friendly and Lisa who has been behind all my treatments is incredible she makes you feel at ease and comfortable and is fantastic at her job I will never go anywhere else for my treatments highly recommend , after going through cancer I lost my glow and now everyone compliments how well I am looking with a glow so it speaks for itself she has also treated my partner for skin tag removals and he is very happy with the results with minimal scarring I will see you soon x Hazel Camilleri2025-04-29Trustindex verifies that the original source of the review is Google. I have been going to Persona for over a year now, the reception team are brilliant so friendly and helpful, Trish, Olivia and Lisa are all so knowledgeable and everything is explained so you feel safe in their hands. I use the Tesla seat which has helped me significantly with my prolapse and pelvic floor, so much so that I have put off surgery that I was due to have , it’s helped so much, I tell everyone about it , if they are struggling as well to give it a try. I have other treatments and all done once highest standards , can’t recommend enough, Hazel Carly VDBK2025-04-16Trustindex verifies that the original source of the review is Google. A welcoming, friendly environment created by the receptionists, who were happy to answer my many questions! Lisa was professional and put me at ease, making sure I was comfortable. I would happily recommend this clinic and would definitely return. Richa Rastogi2025-04-11Trustindex verifies that the original source of the review is Google. I had a wonderful experience with Trisha at Persona Aesthetics. She was incredibly professional, polite, and thorough throughout the entire session. She took her time with the procedure, ensuring everything was done with great care and precision. Her passion for her work truly shows, and it made me feel very comfortable and well taken care of. Will definitely be returning for another microneedling session with her. Highly recommend! Chelsea Clay2025-04-10Trustindex verifies that the original source of the review is Google. Love hydra facials here wouldn’t go anywhere else! Margaret Garcia2025-04-08Trustindex verifies that the original source of the review is Google. Always a friendly welcome when you walk through the door. Lisa as usual administered my Botox wonderfully and always offers a two week aftercare is needed. T.A Roberts2025-03-26Trustindex verifies that the original source of the review is Google. After consulting a few Dermatologists, I found Persona Medical Aesthetics to be the most suitable and the most affordable. I had been on a waiting list for almost a year and decided to go private. I am so glad that I decided to have treatment there for a small cyst on my abdomen. Dr Lisa was absolutely brilliant during the very reasonably priced consultation. Dr Debra who performed the surgery, which took less than an hour, was so calming and generally interested in my chatter as I distracted myself from the actual treatment. I was provided with bandages and aftercare advice, I returned that week to have the stitches removed. You can hardly notice the scar after a few weeks and I was so relieved to have it removed. So thank you Dr Lisa, Dr Debra and their colleagues at Persona. I will definitely recommend their services. Natalie Hughes2025-02-24Trustindex verifies that the original source of the review is Google. I just wanted to say how much I loved my hydra facial treatment done on my 40th birthday 20th Feb. Olivia is really lovely and made me feel at ease before, during and after facial. I felt relaxed. I was happy of how glowy and hydrated my skin became after. My skin is looking better and glad I had it done. I’ll definitely be back to try other treatments also. I’m amazed on how many different things Persona offer. Lastly Lovely reception team too. Thank you for having me. Natalie x Louise Maris2025-02-18Trustindex verifies that the original source of the review is Google. Absolutely love Persona! Lisa is so lovely and such a professional, as are all the staff. I always feel so relaxed and in very good hands when I come here - never rushed and always well informed. Great results. Highly recommended.
